Cell Culture Growth Factors and Hormones
Genscript Corporation FGFR3 beta IIIbBiotin His
Four distinct genes encoding closely related FGF receptors FGF R1-4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation differentiation and apoptosis
CPC Scientific H-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-OH (trifluoroacetate salt) 5MG
The IGF fragment has been synthesized to generate an antibody to the C-peptide region of IGF-I.ONE-LETTER SEQUENCE: GYGSSSRRAPQTMOLECULAR FORMULA: C51H83N19O19MOLECULAR WEIGHT:1266.34STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [82177-09-1], RESEARCH AREA: DiabetesREFERENCES: R.L.Hintz et al., J. Clin. Endocrinol. Metab., 50, 405 (1980)
CPC Scientific H-Ser-Arg-Val-Ser-Arg-Arg-Ser-Arg-OH (trifluoroacetate salt) 5MG
ONE-LETTER SEQUENCE: SRVSRRSRMOLECULAR FORMULA: C38H74N20O12MOLECULAR WEIGHT:1003.13STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [103244-41-3], RESEARCH AREA: DiabetesREFERENCES: R.L.Hintz and F.Liu, J. Clin. Endocrinol. Metab., 54, 442 (1982); W.F.Blum et al., Acta Endocrinol., 111, 271 (1986);
Medchemexpress LLC IFN-lambda 1/IL-29 50ug
IFN-lambda 1 (IL-29) is a member of the Type-III interferon family IFN-lambda 1 signals through a heterodimeric receptor complex comprising IFN receptor 1 (IFNLR1) and IL-10 receptor subunit- (IL-10RB) When IFN-lambda 1 binds with the receptor complex Jak1 and Tyk2 will be activated and leads to subsequent tyrosine phosphorylation of the IFN- R1 and activation of STAT1 and STAT2[1] IFN-lambda 1 modulates immunity in infections and autoimmune diseases[2] IFN-lambda 1/IL-29 Protein Human (HEK293 His) is a recombinant human IFN-lambda 1 (G20-T200) with C-terminal 10 His tag which is produced in HEK293
Medchemexpress LLC CD4 Human HEK293 5ug
The CD4 protein is an integral membrane glycoprotein that plays a key role in immune responses In T cells it serves as a coreceptor for MHC class II molecules interacting with T cell receptors and initiating intracellular signaling pathways CD4 Protein Human (HEK293 Fc) is the recombinant human-derived CD4 protein expressed by HEK293 with C-hFc labeled tag
CPC Scientific H-Gly-Pro-Glu-OH (trifluoroacetate salt) 250MG
This N-terminal tripeptide of IGF-I facilitated the in vitro release of acetylcholine with a several hundredfold higher potency (10-10 - 10-6 M) than intact IGF-I (4 ? 10-8 M), whereas truncated IGF-I lacking the tripeptide GPE, did not show any significant effect. This raises the possibility that GPE may be the active site of IGF-I. - Although the precise mode of action of GPE is still unknown, another study suggests that local administration of GPE is neuroprotective after brain HI injury via glial cells. In addition, systemic administration of GPE showed a more widespread neuroprotective effect. Therefore, GPE may represent a complementary pathway for central and systemic IGF-1's antiapoptotic effects.SEQUENCE: H-Gly-Pro-Glu-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: GPEMOLECULAR FORMULA: C12H19N3O6MOLECULAR WEIGHT: 301.3STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [32302-76-4]SYNONYMS: RESEARCH AREA: DiabetesREFERENCES:L.Nilsson-Hakansson et al., Neuro
Cayman Chemical MSH Release-Inhibiting Factor
A tripeptide with diverse biological activities; binds to rat striatum (Kd = 4.69 nM); decreases immobility of mice in the forced swim test (0.1 mg/kg); increases striatal concentrations of dopamine, DOPAC, 3-MT, and HVA in a mouse model of Parkinson's disease (20 mg/kg); decreases haloperidol-induced vacuous chewing in a rat model of tardive dyskinesia (2 mg/kg); reverses morphine- and enkephalin-induced analgesia in mice in a radiant heat tail-flick assay
Genscript Corporation Heat Stable FGF-basic Human
Heat Stable FGF-basic Human is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family Like other FGF family members FGF-basic has the trefoil structure In vivo FGF-basic is produced by a variety of cells including cardiomyocytes fibroblasts and vascular cells FGF-basic regulates a variety of processes including cell proliferation differentiation survival adhesion motility apoptosis limb formation and wound healing FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury
Genscript Corporation Heat Stable FGF-basic Human
Heat Stable FGF-basic Human is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family Like other FGF family members FGF-basic has the trefoil structure In vivo FGF-basic is produced by a variety of cells including cardiomyocytes fibroblasts and vascular cells FGF-basic regulates a variety of processes including cell proliferation differentiation survival adhesion motility apoptosis limb formation and wound healing FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury
Genscript Corporation GH HumanCHO-expressed
Growth Hormone (GH) is a member of the somatotropin/prolactin family which play an important role in growth control The human GH cDNA encodes a 217 amino acid (aa) and the first 26 aa is a signal peptide By alternative splicing at least four isoforms of GH have been identified The major role of GH in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1 GH stimulates both the differentiation and proliferation of myoblasts and also stimulates amino acid uptake and protein synthesis in muscle and other tissues
CPC Scientific H-Pro-Ala-Leu-Pro-Glu-Asp-Gly-Gly-Ser-Gly-Ala-Phe-Pro-Pro-Gly-His-Phe-Lys-Asp-Pro-Lys-Arg-Leu-Tyr-OH (trifluoroacetate salt) 0.5MG
ONE-LETTER SEQUENCE: PALPEDGGSGAFPPGHFKDPKRLYMOLECULAR FORMULA: C118H173N31O33MOLECULAR WEIGHT:2553.9STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [62031-54-3], RESEARCH AREA: CancerREFERENCES: G. Gimenez-Gallego et al., Science, 230, 1385 (1985)
Medchemexpress LLC FLT3 Mouse HEK293 5ug
FLT3 a receptor tyrosine kinase has diverse functions including kinase activation PI3K binding and ligase binding It plays a vital role in hematopoiesis immune function and tissue development FLT3 is expressed in various tissues like the brain immune system and reproductive system It is involved in diseases like leukemia and cancer The wide functions and tissue-specific expression emphasize FLT3 s importance in health and disease FLT3 Protein Mouse (HEK293 His) is the recombinant mouse-derived FLT3 protein expressed by HEK293 with C-His labeled tag
Advanced Biomatrix PhotoGel 50% DOM Methacrylated Gelatin with LAP Kit
PhotoGel is lyophilized, sterile, medium degree of methacrylation (~50%) methacrylated gelatin. PhotoGel provides 3D gelatin hydrogels with the unique attributes to be prepared at various concentrations and photocrosslinked (requires a photoinitiator) to provide various gel stiffness. The PhotoGel kit consists of purified methacrylated porcine gelatin and a photoinitiator. The gelatin is type A 300 bloom. PhotoGel is produced from methacrylated gelatin where the gelatin has been modified by reacting the free amines, primarily the ε-amines groups of the lysine residues as well as the a-amines groups on the N-termini. The photoinitiator consists of LAP which allows visible light crosslinking of the gelatin at 405 nm.
Genscript Corporation PDGF R beta/CD140bBiotin Hi
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains The PDGF-AA PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities Where as PDGF R alpha binds all three PDGF isoforms with high affinity PDGF R beta binds PDGF-BB only with high-affinity PDGF R plays an essential role in blood vessel development by promoting proliferation migration and recruitment of pericytes and smooth muscle cells to endothelial cells Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites